All functions |
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annotate susie results. this will generate output text files |
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Extract regression coefficients from susie fit |
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Compute sufficient statistics for susie. |
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Converts PLINK genotype data to LD matrices and SNP info files, saves LD matrices as .RDS files and SNP info as .Rvar files |
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Causal inference for TWAS |
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Plot the output of cTWAS at a single locus |
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Create the gene track for the cTWAS locus plot |
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Causal inference for TWAS using summary statistics |
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Summarize and plot cTWAS parameter estimates |
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filter regions based on probality of at most 1 causal effect |
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Harmonize z scores from GWAS to match ld reference genotypes. Flip signs when reverse complement matches, remove/recover strand ambiguous SNPs |
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Harmonize z scores from GWAS to match ld reference genotypes. Flip signs when reverse complement matches. |
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Impute expression |
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Impute expression z scores |
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Get gene and SNP index for each region |
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Predict outcomes or extract coefficients from susie fit. |
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Harmonize GWAS summary statistics and LD reference |
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Prepare .exprvar file |
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Read .pgen file into R |
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Prepare .pvar file |
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Read .bim file into R |
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Read .expr file into R |
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Read .exprvar file into R |
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read variant information for all ld matrices in `ld_Rf`. |
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read variant information associated with a LD R matrix .RDS file. |
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Read pgen file into R |
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Read .pvar file into R |
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Read variant information from .pvar or .bim file into R |
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parallel regions |
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Sum of Single Effects (SuSiE) Regression |
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Iteratively run susie and estimate parameters |
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Iteratively run susie and estimate parameters - RSS version |
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Inferences From Fitted SuSiE Model |
Initialize a susie object using regression coefficients |
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Sum of Single Effects (SuSiE) Regression using summary statistics |
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Perform Univariate Linear Regression Separately for Columns of X |
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combine variant information associated with a LD R matrix .RDS file. |