Single Cell

Spatial reconstruction of single-cell gene expression data

single cell RNA-seq

Problem infer spatial locations of various cell types which will determine the cell fate and behavior RNA staining only assays a small number of transcripts and RNA-seq can measure the global gene expression, but separates the cells from their native spatial context. they develop Seurat to localize the cells by integrating single cell RNA-seq data and in situ RNA patterns. Modeling Overview Figure 1 gives the overview of the method.

Read more →